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We check this website, now substance.io is up and dont blocked for our system and other users of the Internet.
So, answer to question: Is substance Down Right Now?
- NO! substance is up!
If you have problem with access to site substance, and domain substance.io is not avalible.

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• Clear browser cache and/or try other web browser (Chrome, Firefox or Safari). Clearing Your DNS Cache (How to Clear Your DNS Cache and how to flush DNS)
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• Check your network setting, and contact your ISP support if its needed.

Also, check your hosts file (wikipedia about hosts file) for some records about domain substance.io. And try to remove it.

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